Mechanisms of acute axonal degeneration in the optic nerve in vivo
Axonal degeneration is an initial key step in traumatic and neurodegenerative CNS disorders. We established a unique in [...]
Imaging of rat optic nerve axons in vivo
In this protocol, we describe the imaging of single axons in the rat optic nerve in vivo. Axons [...]
ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS
The Rho/ROCK/LIMK pathway is central for the mediation of repulsive environmental signals in the central nervous system. Several [...]
Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.
Many neuropathological and experimental studies suggest that the degeneration of dopaminergic terminals and axons precedes the demise of [...]
Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration
Axonal degeneration is a key initiating event in many neurological diseases. Focal lesions to axons result in a [...]
ROCK inhibition in models of neurodegeneration and its potential for clinical translation
Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic lateral sclerosis are affecting a rapidly increasing population worldwide. [...]